It was the first match-up between the two teams since Metta World Peace violently elbowed James Harden in the head last month.
Oklahoma City jumped on Los Angeles early and never let up, leading by as many as 35 points.
The final score was 119-90.
Russell Westbrook scored 27 points.
Kevin Durant had 25.
James Harden had 17 points.
Game two of the series is Wednesday night at The Peake.
Tipoff is 8:30 p.m.