Have heartburn? Most doctors will tell you to take something called a "proton pump inhibitor."
It's used to reduce the amount of acid in the stomach.
But now doctors are finding that half of reflux sufferers don't get relief from these medications.
PPIs, or acid reducers are popular pills, the third largest-selling drug in the US, with 113 million prescriptions being filled each year.
But it may be a waste of time for many.
A different kind of acid reflux, non-erosive reflux, has symptoms like tightness in the chest, phlegm in the throat and voice loss.
For some, it's not the stomach acid causing the problem, it's actually other enzymes in the stomach fluid.
Experts say doctors should try to figure out the cause, not just treat the symptoms.
If you can't get relief, talk with your doctor about other options.