Former OU quarterback Sam Bradford suffered an injury to his left knee on Sunday, and had to leave the St. Louis Rams game at Carolina.
Bradford was scheduled to undergo an MRI after the team landed in St. Louis to determine the severity of the injury.
Bradford was injured when he was pushed out of bounds while scrambling in the fourth quarter.
Both NBC and ESPN reported Sunday night sources indicate Bradford suffered a torn ACL and will miss the rest of the season.
Bradford was 21 for 30 for 255 yards, with a touchdown pass and an interception, as the Panthers beat the Rams 30-15.
Three former OSU stars helped the Dallas Cowboys beat Philadelphia 17-3 on Sunday.
Joseph Randle got his first career start at running back, in place of the injured former Sooner DeMarco Murray.
Randle carried it 19 times for 65 yards and caught three passes for 28 yards.
Former OSU receiver Dez Bryant had eight catches for 110 yards in the game, while former OSU kicker Dan Bailey kicked a 38-yard field goal.
It was a bedlam battle of tight ends as Detroit hosted Cincinnati.
Former OU tight end Jermaine Gresham had four catches for 64 yards for the Bengals, while former Cowboy Brandon Pettigrew had three catches for seven yards, and caught a three-yard touchdown pass for the Lions.
The Bengals won the game 27-24.
Former OSU quarterback Brandon Weeden had a tough day, completing just 17 of 42 passes for 149 yards, with a touchdown and an interception for Cleveland, as they lost at Green Bay, 31-13.
Former OSU receiver Justin Blackmon caught six passes for 58 yards for Jacksonville.
The Jaguars lost at home to San Diego, 24-6.
Former Heritage Hall star Wes Welker had seven catches for 96 yards, but Denver lost at Indianapolis, 39-33.