The home between Lake Thunderbird and Lake Stanley Draper caught fire just before 5:30 a.m.
Crews said the roof of the 4,000 sq. ft. house was started to collapse as soon as they got inside.
Authorities said OG&E has been called to the 2-alarm fire at the home on the 14400 block of Sauna Ln. because power lines are down as well.
Officials have not said what sparked the fire.