Oklahoma got several big offensive plays to score 45 unanswered points and pull away to beat Iowa State 48-10 on Saturday at Owen Field in Norman.
In a very uneventful first quarter, neither team could muster much offense.
Oklahoma stopped a Cyclone drive when Quentin Hayes got an interception after a pass was tipped by Stanvaon Taylor, but the Sooners couldn't do anything with the turnover and had to punt.
Iowa State started a drive late in the first quarter, maraching 14 plays in 69 yards, capping the drive with a 4-yard touchdown run by ISU quarterback Sam Richardson early in the second quarter to put the Cyclones up 7-0.
Oklahoma responded by driving to the ISU 5, but had to settle for a 22-yard field goal by Michael Hunnicutt to make it 7-3 Iowa State.
On the drive, OU quarterback Blake Bell was hit hard on a running play and had to leave the game.
Trevor Knight came on to replace Bell and lead OU to the field goal.
Iowa State responded with a field goal of their own, getting a 29-yarder from Cole Netten to extend their lead to 10-3.
It was the OU special teams which gave the Sooners a spark.
Late in the first half, Jalen Saunders returned a punt 90 yards for a touchdown to tie the game at 10 with 1:09 left in the first half.
The Sooners kept the big plays coming in the third quarter.
On the second play of the third quarter, Damien Williams scored on a 69-yard touchdown run to put the Sooners up 17-10 with 14:17 to play in the third quarter.
OU's next possession resulted in a 32-yard field goal by Hunnicutt to make it 20-10.
It was another big play that added to the Sooner lead, as Brennan Clay scored on a 63-yard touchdown run to put OU up 27-10.
OU poured on 21 more points in the fourth quarter.
Trevor Knight scored on a 56-yard touchdown run early in the quarter to make it 34-10 Sooners.
Knight rushed for 123 yards on just 10 carries.
As a team, Oklahoma rushed for 405 yards, a record for the Bob Stoops era.
Oklahoma's next drive ended with a 19-yard touchdown run from Damien Williams, who finished the day with 128 yards rushing on 10 carries.
Redshirt freshman Kendal Thompson came in at quarterback for OU in the fourth quarter, picking up 13 yards on his first carry.
He then went deep to Lacoltan Bester for a gain of 44 yards, which set up the only touchdown pass of the day, as Thompson found Aaron Ripkowski for a 3-yard score to make it 48-10 Sooners.
It was senior day in Norman, and seniors Trey Millard and Gabe Ikard were honored as co-winners of the Don Key Award, which goes to OU's outstanding senior player, on and off the field.