Oklahoma State controlled the game in the second half to break up a tight game and beat Iowa State 37-20 at Boone Pickens Stadium in Stillwater Saturday.
Both offenses were sluggish in the opening period.
Iowa State forced the only turnover, with Sam Richardson intercepting Daxx Garman and returning it 17 yards to the OSU 46.
The Cyclones were driving as the quarter ended, and had the ball on the Cowboys' 13-yard-line.
The OSU defense came up big to halt the Iowa State drive, as Josh Furman sacked the Cyclone quarterback, also named Sam Richardson.
ISU settled for a 34-yard field goal from Cole Netten to take a 3-0 lead.
Oklahoma State's ensuing possession ended with a turnover, as Garman was picked off by Nigel Tribune.
Iowa State got the first big offensive play of the game on a 53-yard pass from Richardson to DeVondrick Nealy.
That set up another 34-yard field goal from Netten to give the Cyclones a 6-0 lead with 7:02 to play in the second quarter.
Oklahoma State answered with their first scoring drive.
Garman completed passes to Marcell Ateman for 16 and Jhajuan Seales for 20 before Garman was sacked on 3rd down.
Ben Grogan kicked a 34-yard field goal to cut the Iowa State lead in half, 6-3.
The Cowboys theatened to take the lead on their next possession, but the drive stalled at the ISU 13, and Grogan kicked a 30-yard field goal to tie the game 6-6 with 43 seconds left in the first half.
It appeared that would be the score at halftime, but on the kickoff, two Iowa State returners allowed the ball to get between them, and Elliott Jeffcoat recovered the loose ball at the ISU 11-yard line.
In two plays, OSU got down to the one-yard line, but threw two incompletions, and then with no timeouts and just seven seconds left in the half, Desmond Roland appeared to be stopped short of the goal line on 3rd down and the clock ran out to end the first half.
The play was reviewed on replay, and while it wasn't real clear, the replay official ruled Roland just barely got the ball across the plane of the goal line for a touchdown and the Cowboys went to the lockerroom leading 13-6 at halftime.
OSU quickly doubled the lead on the first play of the second half, as Tyreek Hill returned the second half kickoff 97 yards for a touchdown to give the Cowboys a 20-6 lead.
Hill finished with 221 all-purpose yards.
With the momentum all in OSU's favor, Iowa State responded with their first touchdown drive.
Twice during the drive, OSU came up with a turnover that was nullified by penalty, first on a Seth Jacobs fumble recovery, then on a Ramon Richards interception in the end zone.
Iowa State took advantage of the second and third life, with Sam Richardson passing to E.J. Bibbs, who made a great one-handed catch for a 17-yard touchdwon to cut OSU's lead to 20-13 with 10:02 to play in the third quarter.
Oklahoma State responded with Garman passing to Seales for a 40-yard touchdown to extend the lead to 14 again, 27-13, with 7:54 to play in the third quarter.
Garman was 26 of 41 passing for 271 yards and the one touchdown.
After forcing Iowa State to punt without getting a first down, the Cowboys extended the lead.
Garman found Brandon Sheperd for a gain of 30, which set up a 34-yard field goal by Grogan to make OSU's lead 30-13 with 4:30 to play in the third quarter.
Oklahoma State added to the lead on the first play of the fourth quarter, with Desmond Roland scoring on a six-yard touchdown to cap a 10-play, 72-yard drive and make it 37-13 Cowboys.
Roland finished with 95 yards rushing on 19 carries with two touchdowns.
Iowa State closed the scoring with a Sam Richardson 7-yard touchdown pass to Bibbs to make it 37-20 with just under a minute to play.
OSU improves to 4-1 and 2-0 in Big 12 play, while Iowa State drops to 1-4, 0-3 in the conference.
The Cowboys will visit Kansas next Saturday for a 3:00 kickoff in Lawrence.