Baylor responded to a 14-3 deficit with 45 straight points and beat Oklahoma 48-14 at Owen Field in Norman on Saturday.
The Bears handed Oklahoma their worst home loss since 1997, and their first back-to-back home losses since 1998.
It was Baylor's first win ever against OU in Norman in 12 games.
It also matched the worst regular season loss in the Bob Stoops era, equaling the 34-point loss to Oklahoma State in 2011.
The only greater deficit under Stoops was USC's 36-point win in the 2005 Orange Bowl, which was for the national championship.
Neither team could get a first down on their first possession, then Baylor began to move the ball on their second possession.
On 4th and 1 from the OU 17, Baylor was going to go for it, and the Sooners were called for having 12 men on the field, giving the Bears a first down at the OU 12.
This time the Sooner defense held, as Dominique Alexander led several defenders to sack Bryce Petty on 3rd down, and Baylor had to settle for a 34-yard field goal from Chris Callahan to take a 3-0 lead with 8:20 to play in the first quarter.
Oklahoma responded with an 11-play, 64-yard drive, capped by an 8-yard touchdown pass from Trevor Knight to Michiah Quick to put the Sooners on top 7-3 with 5:07 left in the first quarter.
Quick had six catches for 94 yards.
Knight had an 18-yard run in the drive in which he leaped a Baylor defender to get a first down.
The next time OU got the ball the Sooners added to the lead, with Knight passing to Durron Neal for a 9-yard touchdown to make it 14-3 Sooners with 37 seconds left in the first quarter.
The second quarter was a different story, as Baylor dominated the rest of the first half.
The Bears started their next drive late in the first quarter, and finished early in the second quarter, going 75 yards in 10 plays, with Petty passing to Corey Coleman for a 33-yard touchdown to draw Baylor within four at 14-10.
Coleman had 15 catches for 224 yards.
Then the game really started to turn on OU's next possession.
Knight was intercepted by Bryce Hager, who returned it 36 yards to the Sooner 1-yard line.
Devin Chafin dived over the top for a score on the next play and Baylor led for good at 17-14 with 10:50 to play in the first half.
Oklahoma marched to the Baylor 14 on their next possession, but the drive stalled and Michael Hunnicutt missed a 31-yard field goal.
Baylor then responded with a long, clock-eating drive, going 80 yards in 16 plays, with Chafin scoring on a 2-yard touchdown run to extend the Bear lead to 24-14 with 3:38 to play in the second quarter.
The Bears got the ball to start the third quarter, and controlled the ball again, going 75 yards in 10 plays, with Corey Coleman scoring on a 5-yard touchdown run to make it 31-14 Baylor with 12:10 to play in the third quarter.
OU did not get a first down on their ensuing possession, and Baylor then marched to another score.
Bryce Petty passed to Coleman for a gain of 48 yards, setting up a Shock Linwood 3-yard touchdown run to extend the BU lead to 38-14 midway through the third quarter.
The drive was 72 yards in 7 plays.
Petty was 32 of 42 passing for 387 yards.
OU finally got a big offensive play on their next possession, with Alex Ross finding room around the left side for a gain of 50.
The drive ended with no points, however, as on 4th and 2 from the Baylor 3, Knight scrambled to find a receiver and threw incomplete in the end zone.
Baylor bridged the third and fourth quarters with another scoring drive, as Callahan kicked a 24-yard field goal to make it 41-14 Bears with 12:38 to play in the game.
On Oklahoma's next possession, Knight was sacked by Grant Campbell on 3rd down and stayed down for several minutes before being carted off the field with an unknown injury.
Knight was just of 12 of 27 passing for 146 yards.
Baylor then got the ball and marched 33 yards in 6 plays to extend the lead, with Shock Linwood scoring on a 14-yard touchdown run to make it 48-14 with 7:37 to play.
Linwood finished with 87 yards on 23 carries and two touchdowns.
The Bears dominated the team statistics, with a 31-13 edge in first downs, 544-319 in total yards, and 396-148 in passing yards, plus had an 11 minute edge in time of possession.
Baylor ended a 37-game losing streak to ranked teams on the road, a streak that dated back to 1991.
Baylor also achieved another impressive feat, becoming the first team at the major college level to score at least 34 points against OU in four straight meetings.
For Oklahoma, it was their worst home loss since Texas A&M beat the Sooners 51-7 in 1997.
It's also the first time OU has lost back-to-back home games since losing to California and Colorado in 1998.
Oklahoma played without receiver Sterling Shepard, who warmed up before the game, but wasn't able to play through his groin injury suffered last week against Iowa State.
OU did welcome back Keith Ford, who had not played since suffering an ankle injury against Tennessee in mid-September.
Oklahoma played in their alternate home uniforms, with crimson jerseys and white helmets and pants.
The Sooners drop to 6-3 on the season, 3-3 in Big 12 play.
Baylor improves to 8-1 overall, 5-1 in conference action.
The Sooners visit Texas Tech next Saturday at 2:30 in Lubbock.