COVID-19 and the elderly: What’s the connection?

This is an archived article and the information in the article may be outdated. Please look at the time stamp on the story to see when it was last updated.

OKLAHOMA CITY (KFOR) – The Oklahoma Medical Research Foundation says research shows COVID-19 has hit elderly communities hard, but why?

According to the Centers for Disease Control and Prevention, 8 out of every 10 COVID-19 deaths in the U.S. have occurred in adults age 65 and older. This age group also accounts for upward of 70 percent of all coronavirus hospitalizations nationwide.

 But why?

Officials with OMRF say the prevalence of underlying health conditions like diabetes and heart disease as we grow older plays a big role.

However, experts at OMRF say there’s another culprit that bears part of the blame: our immune system, the biological network whose job is to protect us against viruses.

“The general line of thinking is that immunity falters with normal aging, just like our muscle mass and cognitive function,” said Hal Scofield, M.D., a physician-scientist at OMRF. “You don’t see pro athletes playing after age 50. We have a shelf life physically, and that goes for immunity, too.”

That waning immunity leaves older people more prone to serious complications not only from COVID-19 but from seasonal illnesses like the flu.

T cells and B cells, special types of white blood cells involved in the immune response, offer clues to why immunity declines with age, according to OMRF immunologist Susan Kovats, Ph.D.

“We don’t know all the specifics behind the decline in immune function with aging, but we do know that both T cell and B cell function deteriorates with age,” she said.

T cells are made by a small organ in your chest called the thymus, “which slowly shrinks over time and is essentially gone in your adult years,” said Kovats.

Meanwhile, she said, “The ability of B cells to produce highly specific antibodies that inactivate viruses also decreases with age.” B cell numbers decline to a greater extent in elderly men, Kovats noted, “which may explain why they are more likely to die from severe Covid-19 disease.”

These age-related declines explain why, for example, a virus like shingles tends to emerge from a weakened immune system later in life.

“If you’ve had chickenpox, the shingles virus stays in your body forever,” said Scofield, who also serves as associate chief of staff for research at the Oklahoma City VA. “When you’re young, your immune system keeps the virus in check. As you age, your body begins to lose its defenses and that increases your likelihood of getting shingles.”

Weakened immunity has also made the annual flu shot less effective in the elderly, with the CDC reporting that only 25 percent of people age 50 and older were protected during the 2018-19 flu season.

“The immune responses to vaccines are not as good overall in the elderly, and this is a legitimate concern as Covid-19 vaccines are hurried to the finish line,” said Kovats. “A lot of work is being done to try to understand why the immune response weakens, and significant effort has gone into changing how vaccines are made for this age group in order to solicit better immune responses.”

Researchers at OMRF and across the country are investigating the mysteries of aging, as well as the immune system, to better protect a population that now counts more than 50 million Americans over the age of 65.

“COVID-19 is unlike anything the body has ever seen before, and older people do not respond well to pathogens or viruses they’ve never been exposed to,” Scofield said. “This is going to be a challenge, but the more we learn about how the immune system works, the better we’ll be at protecting our seniors in future outbreaks.”

Copyright 2021 Nexstar Media Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

Latest News

More News

Pay it 4Ward

More Pay It 4ward

National News

More U.S. & World

Washington D.C.

More Washington

Your Local Election HQ

More Your Local Election HQ

Daily Oklahoma Coronavirus Data


Contact In Your Corner Team

Latest News

More News


image of QR Code

KFOR Digital Originals

More Digital Original

Follow @KFOR on Twitter