The men were playing the game in Encinitas when they fell more than 75 feet to the beach below. According to officers, the men got distracted while trying to catch Pokémon.
Crews at the scene used a rope to rescue one of the men. Neither man was seriously injured.
It was released on July 7 and has been downloaded over 10 million times to Android and Apple devices.
Players capture the virtual creatures and can amass a collection and train them to battle Pokémon held by other players.
The game is currently only available as an app for smartphone holders in Australia, New Zealand, the U.S., Germany and the U.K.